The stereochemical course of phosphoryl transfer catalysed by glucose 6-phosphatase
- 1 March 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 201 (3) , 665-668
- https://doi.org/10.1042/bj2010665
Abstract
Rat liver microsomal glucose 6-phosphatase catalyses phosphoryl transfer between D-glucose 6-[(R)-16O,17O,18O]phosphate and D-glucose with retention of configuration at the phosphorus atom. Since individual phosphoryl-transfer steps appear in general to occur with inversion of configuration, this observation is most simply interpreted in terms of a double-displacement mechanism with a phosphoryl-enzyme intermediate. Such an intermediate has been proposed previously from kinetic and 32P-labelling experiments.This publication has 12 references indexed in Scilit:
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