More on Beta-Blockers in Pregnancy

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To the Editor: The excellent review by Rubin (November 26, 1981) and the subsequent correspondence (April 1 issue) on the use of beta-blockers in pregnancy,1 , 2 raise important issues. Rubin cites the study completed at the National Women's Hospital, Auckland,3 by Dr. J. V. Hodge and me, as evidence supporting the effective use of these agents in the treatment of hypertension in pregnancy. Several aspects of our study require qualification. In our series of 44 moderately or severely hypertensive pregnant women (diastolic pressures >105 mm Hg, Phase 5), the beta-blocker oxprenolol was seldom sufficient for satisfactory control of blood pressure. An . . .

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