Hydroxylysine Metabolism in Rats, Mice, and Chickens

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Abstract
Rats deficient in vitamin B6 exhibited a decreased ability to metabolize 5-hydroxy-L-lysine-6-14C to 14CO2 as compared to normal animals. Under vitamin B6-deficient conditions, phosphohydroxylysine accumulated in the kidneys and liver. Administration of pyridoxine to the deficient rats prior to the hydroxy-L-lysine reduced the phosphate ester concentration to normal levels. These experiments confirm the in vivo involvement of hydroxylysine kinase and O-phosphohydroxylysine phospho-lyase in the degradation of hydroxylysine. Using the four individual isomers of hydroxylysine-6-14C, the general patterns of hydroxylysine degradation in the rat, the mouse and the chicken were compared. All three species degraded the L-isomers to CO2 via glutarate. Allohydroxy-D-lysine, which is metabolized to the terminal product, hydroxypipecolate, in the rat, was not metabolized by the mouse, but was degraded to CO2 by the chicken. In all three species, hydroxy-D-lysine formed little CO2 or compounds found in the urine.

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