THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
Open Access
- 1 August 1950
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 92 (2) , 121-128
- https://doi.org/10.1084/jem.92.2.121
Abstract
1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their possible biological significance briefly discussed.Keywords
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