Marek's Disease: Effects of B Histocompatibility Alloalleles in Resistant and Susceptible Chicken Lines

14 January 1977

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 195 (4274) , 193-195
https://doi.org/10.1126/science.831269

Abstract

Lines of chickens selected from a common ancestral population for either resistance or susceptibility to Marek's disease developed contrasting frequencies of particular B alloalleles. Comparison of inoculated sibs in backcross-families revealed that the B alloalleles characterizing the two lines accounted for an eightfold difference in tumor incidence. This genetic difference in tumorigenesis associated with the alloalleles of the major histocompatibility complex is probably expressed through the cell-mediated immune system.

This publication has 32 references indexed in Scilit:

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.
The Journal of Experimental Medicine, 1975
Relation between the Major Histocompatibility (B) Locus and Autoimmune Thyroiditis in Obese Chickens
Science, 1974
Evidence for an association between immune responsiveness of chicken to (T, G)‐A–L and the major histocompatibility system
European Journal of Immunology, 1974
Genetic determination of tuberculin hypersensitivity in chicken inbred lines
European Journal of Immunology, 1974
Marek's Disease: Chromosome Studies of Resistant and Susceptible Strains
Published by JSTOR ,1970
GENETIC RESISTANCE AND SUSCEPTIBILITY TO MAREK’S DISEASE
Canadian Journal of Animal Science, 1970
THE RELATIONSHIP OF BLOOD GROUPS TO SKIN GRAFT SURVIVAL IN CHICKENS
Transplantation, 1964
Abstracts of Papers read at the hundred and fortieth meeting of the Society held on 9th and 10th November 1962, at the Middlesex Hospital Medical School, London, W.1.
Heredity, 1963
Blood Groups and Splenomegaly in Chick Embryos
Science, 1962
Relationship of Blood Type to Histocompatibility in Chickens
Science, 1961