Restimulation in Secondary MLC by Autologous Non-T Cells
- 1 June 1979
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 9 (6) , 493-498
- https://doi.org/10.1111/j.1365-3083.1979.tb03276.x
Abstract
Lymphocytes sensitized in mixed leucocyte culture (MLC) were restimulaied with non-T or complete cells. Cells primed against autologous non-T cells and restimulated with autologous cells gave responses with the kinetics of a secondary response. In contrast, cells primed against either type of autologous cell responded to restimulation by allogeneic cells with the kinetics of a primary MLC response. Following priming against alloantigens good secondary responses against both complete and non-T allogeneic restimulators were seen. Restimulation with auto-logous non-T colts, but not autologous complete cells, also led to secondary responses. The observation of” different responses to antigens expressed on non-T autologous lymphocytes, in comparison to complete cells, implies that the secondary MLC involves more than a response against alloantigen. Allogeneic and autologous MLC may he qualitatively different phenomena. the latter representing the recognition of identifying structure's between interacting populations of cooperating cells.This publication has 12 references indexed in Scilit:
- Occurrence of restricted suppressor T-cell activity in man.The Journal of Experimental Medicine, 1977
- Linear density gradient separation of human lymphocyte subsetsEuropean Journal of Immunology, 1977
- Phenotyping of HLA-D-region products by negative and positive mixed lymphocyte reactionsImmunogenetics, 1976
- Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes.The Journal of Experimental Medicine, 1976
- Secondary Responses of Human Lymphocytes to Alloantigens In VitroScandinavian Journal of Immunology, 1975
- HL-A LD (Lymphocyte Defined) Typing: A Rapid Assay with Primed LymphocytesScience, 1975
- H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.The Journal of Experimental Medicine, 1975
- FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTESThe Journal of Experimental Medicine, 1973
- UNRESPONSIVENESS TO SELF ANTIGENSThe Lancet, 1971