Atrial Natriuretic Factor, Catecholamines, and Natriuresis

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To the Editor: The finding by Kuribayashi and co-workers (May 30 issue),1 coupled with the observation of decreased plasma epinephrine levels after intravenous injection of an atrial natriuretic peptide (human a-atrial natriuretic peptide [α-hANP]) in normal subjects,2 raises the possibility of an inhibitory control of catecholamine synthesis or release by atrial natriuretic factor (or factors) (ANF), which has been previously suggested.3 An interesting background to this possible interaction is the observation that sympathectomized rats have an attenuated natriuretic response to treatment with ANF.4 In a preliminary study we tested the effect of α-hANP (Bachem, Switzerland) on catecholamine biosynthesis in human . . .