Interactions between radiation-sensitive mutations in double-mutant haploids of Dictyostelium discoideum
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 167 (3) , 265-270
- https://doi.org/10.1007/bf00267418
Abstract
Haploid strains of Dictyostelium discoideum carrying radiation-sensitive mutations in both the radA and radC genes are more sensitive to UV light irradiation than the “additive” sensitivity of the single-mutant haploids. This synergistic interaction indicates that the radA and radC gene products are involved in two different pathways of repair following UV-induced DNA damage. Double-mutant haploids bearing mutations in both the radA and radB genes have the same sensitivity as the radB single mutant indicating that the radA and radB gene products are involved in the same repair pathway.This publication has 32 references indexed in Scilit:
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