The Nephrotoxicity of Antimicrobial Agents

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Abstract
VancomycinVancomycin is excreted chiefly by the kidney, with more than 80 per cent of the administered dose recovered in the urine within 24 hours.84 Its half-life is six hours. In patients with impaired renal function, very high serum concentrations accumulate,85 , 86 and the drug is not removed by either hemodialysis or peritoneal dialysis.Animal studies have found vancomycin to have little nephrotoxicity, although the highest concentrations of vancomycin are recovered in the kidneys of the animals post mortem.87 , 88 Although ototoxicity due to vancomycin has been clearly established in man, nephrotoxicity has not. Direct injection of 2-g doses intravenously into healthy . . .

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