Synthesis of Epstein-Barr Virus After Activation of the Viral Genome in a “Virus-Negative” Human Lymphoblastoid Cell (Raji) Made Resistant to 5-Bromodeoxyuridine
- 1 January 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (1) , 78-82
- https://doi.org/10.1073/pnas.69.1.78
Abstract
The Raji line of human lymphoblastoid cells, which does not show expression of Epstein-Barr virus, was made resistant to 5-bromodeoxyuridine. Within several weeks after removal of the drug, Epstein-Barr virus particles were detected in the cells. The sequence of virus appearance in the 5-bromodeoxyuridine-resistant cells indicated drug-induced activation of a repressed Epstein-Barr virus genome.Keywords
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