The Effect of Atropine on Secretin Release and Aspirated Bicarbonate Secretion after Duodenal Acidification in Man

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Abstract
The effect of duodenal instillation of HCl on peripheral plasma immunoreactive secretin (IRS) concentration without or with a constant i.v. infusion of atropine, was studied in 8 healthy volunteers. Without atropine infusion, IRS increased from 1.2 .+-. 0.3 pmol/l to a peak value of 17.1 .+-. 4.4 pmol/l. The volume of duodenal aspirates increased from 0.74 .+-. 0.12 ml/min to 5.03 .+-. 0.46 ml/min and the bicarbonate output from 7.6 .+-. 1.7 .mu.mol/min to 349 .+-. 39 .mu.mol/min. With atropine infusion (bolus of 500 .mu.g + 750 .mu.g/h of atropine, sulfate), IRS increased from 1.4 .+-. 0.3 pmol/l to 14.8 .+-. 3.6 pmol/l. The volume of the duodenal aspirates increased from 0.71 .+-. 0.08 ml/min to 2.76 .+-. 0.37 ml/min and the bicarbonate output from 4.0 .+-. 1.6 .mu.mol/min to 142 .+-. 33 .mu.mol/min. The integrated IRS response to acidification was 18% lower during atropine infusion (P < 0.05). Both the aspirated flow rate from the duodenum and the bicarbonate output were markedly reduced by atropine infusion, 45% and 59%, respectively, (P < 0.005).

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