SECRETION OF PANCREATIC JUICE AFTER CUTTING THE EXTRINSIC NERVES

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Abstract
In the study of the effects on the external secretion of the pancreas of cutting the vagus or splanchnic nerves it was found that: Cutting the vagus nerves or blocking them by means of drugs was followed by temporary absence of the secretion of pancreatic juice which normally follows inj. of peptone solns. into the intestine. Twenty-four hrs. or more following vagotomy pancreatic juice was again secreted in response to peptone stimulation but in less than normal amts. The response to HCl was also less than normal. Vagotomy did not affect the vol. or conc. of pancreatic juice secreted in response to soap in the intestine. The total N content of the pancreatic juice was not consistently altered by vagotomy, regardless of the stimulus. Cutting the major splanchnic nerves caused no consistent changes in the response of the pancreas to intestinal stimuli.