THE PANCREATIC SECRETAGOGUE ACTION OF PRODUCTS OF PROTEIN DIGESTION

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Abstract
Products of protein digestion act in the intestine as stimuli for the external secretory function of the pancreas. Their effectiveness is not dependent on the coincident flow of bile into the intestine nor on the secretagogue action of water or acid. The secretion produced by peptone stimulation has higher specific gravity and contains many times more N per ccm. than that produced by water, acid or secretin. There are wide variations in effectiveness as stimuli for the pancreas among various commercial peptones and protein digests prepd. in the laboratory. Among commercial peptones the more effective products are those having the higher % of proteose. The properties of the secretion are such that it could not be produced by secretin stimulation alone. The secretion elicited by peptones resembles that caused by pilocarpine and other stimuli acting through or on the secretory nerves. Hence, the conclusion is drawn that the peptones act through a nervous mechanism.

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