A QUANTITATIVE STUDY OF ACID IN THE INTESTINE AS A STIMULUS FOR THE PANCREAS

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Abstract
A method is descr. for the study of pancreatic function without a pancreatic fistula. An attempt was made to determine the pH at which acid in the intestine begins to act as a stimulus for pancreatic secretion. Variations in pH threshold were observed but these were interpreted as due to differences in the ability of buffer solns. prepared with different acids to maintain their acidity in the intestine. The pH threshold for the more efficient buffers was near pH 5.0. The true threshold, if it could be detd., would not be below pH 5.0. The practical acid threshold for causing a significant amt. of secretion in the dog digesting raw meat was estimated to be near pH 4.0. This degree of acidity was commonly present in the dog''s duodenum during meat digestion. Under some physiological conditions the acidity of the intestinal contents is adequate to stimulate the pancreas.

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