Effects of Acute Behavioral Stress on Plasma and Cerebrospinal Fluid ACTH and β-Endorphin in Rhesus Monkeys

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Abstract
To elucidate the effect of acute behavioral stress on plasma and cerebrospinal fluid (CSF) concentrations of adrenocorticotropic hormone (ACTH) and β-endorphin, rhesus monkeys were subjected to 30 min of confinement stress. Simultaneous plasma and. CSF samples revealed no significant change in CSF ACTH or β-endorphin up to 120 min after the onset of the stress despite significant elevations in plasma cortisol, ACTH, and β-endorphin. It is suggested that acute behavioral stress does not alter CSF ACTH or β-endorphin, and that this information may be clinically useful for future human studies of CSF ACTH and β-endorphin in neuropsychiatric illnesses.