Acute effects of MK421, a new angiotensin coverting enzyme inhibitor, in man.
Open Access
- 1 January 1983
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 141 (4) , 417-422
- https://doi.org/10.1620/tjem.141.417
Abstract
KASAI, Y., ABE, K., YASUJIMA, M., TAJIMA, J., SEINO, M., CHIBA, S., SATO, K., GOTO, T., OMATA, K., TANNO, M. and YOSHINAGA, K. Acute Effects of MK421, a New Angiotensin Converting Enzyme Inhibitor, in Man. Tohoku J. exp. Med., 1983, 141 (4), 417-422 Acute effects of MK421 were examined in 11 male normal volunteers. Oral administration of 5mg of MK421 did not induce any changes in blood pressure or pulse rate. Plasma renin activity increased significantly from 7.3±2.9ng/ml to 22.2±7.1 (pp<0.02) following the administration of MK421. The present results show that an increased renin release induced by MK421 is independent of change in blood pressure, and also suggest that MK421 may have a direct action on the renal tubules.Keywords
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