Hurler and Hunter Syndromes: Mutual Correction of the Defect in Cultured Fibroblasts
- 1 November 1968
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3853) , 570-572
- https://doi.org/10.1126/science.162.3853.570
Abstract
The biochemical defect of cultured skin fibroblasts from Hurler or Hunter patients (faulty degradation of sulfated mucopolysaccharide, resulting in excessive intracellular accumulation) may be corrected if cells of these two genotypes are mixed with each other or with normal cells. The effect is mediated by substances released into the medium.Keywords
This publication has 5 references indexed in Scilit:
- The defect in Hurler's and Hunter's syndromes: faulty degradation of mucopolysaccharide.Proceedings of the National Academy of Sciences, 1968
- HURLER'S SYNDROME: A GENETIC STUDY OF CLONES IN CELL CULTURE WITH PARTICULAR REFERENCE TO THE LYON HYPOTHESISThe Journal of Experimental Medicine, 1967
- Hurler's syndrome: biosynthesis of acid mucopolysaccharides in tissue culture.Proceedings of the National Academy of Sciences, 1966
- HURLER'S SYNDROMEThe Journal of Experimental Medicine, 1966
- Hurler's Syndrome: Demonstration of an Inherited Disorder of Connective Tissue in Cell CultureScience, 1965