PERIPHERAL NERVE INJURIES FROM ADMINISTRATION OF PENICILLIN
- 23 July 1949
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 140 (12) , 1008-1010
- https://doi.org/10.1001/jama.1949.02900470012003
Abstract
Toxic effects of penicillin have been described in experimental animals and human beings affecting the meninges, nerve fibers and the cerebral cortex. Walker, Johnson and Kollros1 demonstrated that penicillin injected into the cortex of monkeys or men induced convulsions. They also showed, by duplicating their results with pure crystalline penicillin, that these convulsions were not due to impurities that may be found in crude penicillin. Walker and Johnson2 and later Walker, Johnson and Kollros1 demonstrated convulsions as an indication of toxicity when penicillin was applied to the cerebral cortex of cats, dogs, monkeys and human beings. They observed electroencephalographic changes which paralleled these convulsive and subconvulsive states. Borkowski and Forster3 stated the belief that these results might have been obtained from the intracortical injections, but later supported the work of Walker and his group by reproducing the convulsions and electroencephalographic changes by applying penicillin-soaked pledgets toKeywords
This publication has 4 references indexed in Scilit:
- CONVULSANT EFFECTS OF PENICILLIN ON THE CEREBRAL CORTEXJournal of Neuropathology and Experimental Neurology, 1947
- COMPLICATIONS OF INTRATHECAL USE OF PENICILLINJAMA, 1946
- THE TREATMENT OF PNEUMOCOCCIC MENINGITIS WITH PENICILLINJAMA, 1945
- PENICILLIN CONVULSIONS - THE CONVULSIVE EFFECTS OF PENICILLIN APPLIED TO THE CEREBRAL CORTEX OF MONKEY AND MAN1945