EFFECTS OF ESTRADIOL ON THE METABOLISM OF ARACHIDONIC-ACID BY AORTAS AND PLATELETS IN RATS
- 1 January 1981
- journal article
- research article
- Vol. 664 (2) , 291-297
Abstract
Estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. To see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. No significant effect on thromboxane biosynthesis in platelets is observed. Estradiol apparently would be a protective hormone in atherosclerotic heart disease.This publication has 7 references indexed in Scilit:
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