RNA Degradation Induced by the Herpes Simplex Virus vhs Protein Proceeds 5′ to 3′ In Vitro
Open Access
- 1 December 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (23) , 13391-13394
- https://doi.org/10.1128/jvi.78.23.13391-13394.2004
Abstract
The herpes simplex virus virion host shutoff protein (vhs) is an mRNA-specific RNase that contributes to shutoff of host protein synthesis. We show here that vhs-induced mRNA decay proceeds 5′ to 3′ in an in vitro assay system derived from rabbit reticulocyte lysate.Keywords
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