Epidermotropism in Melanoma

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Abstract
Multiple malignant melanocytic lesions developed in a 54-yr-old man 4 yr after a primary malignant melanoma (Clark level IV) was excised and 2 mo. after taking L-dopa for Parkinsonism. Several of the recurrent lesions that showed junctional melanocyte components were considered primary melanomas and it was suggested that L-dopa was responsible for malignant transformation of nevi and for rapid progression of the disease. The case was re-examined and on recent evidence it is likely that these lesions were epidermotropic metastases and that L-dopa played no part in the progress of this unusual tumor.