Levodopa therapy and malignant melanoma

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Abstract
Concern was voiced over a role for levodopa in the induction or stimulation of growth of cutaneous malignant melanoma. Prospective query of 1099 patients of the Melanoma Clinical Cooperative Group at the time of presentation of their primary melanoma showed only 1 patient who was taking levodopa for Parkinson''s disease. Levodopa, if a factor in the induction of melanoma, must be playing an inconsequential role in the rapid rise in incidence observed for this tumor over the past decade.