RENAL EFFECTS OF ENFLURANE ANESTHESIA IN FISCHER 344 RATS WITH PRE-EXISTING RENAL-INSUFFICIENCY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 211  (1) , 36-41
Abstract
Chronic renal insufficiency was produced surgically in Fischer 344 rats to evaluate the effects of enflurane anesthesia in animals with impaired renal function. Three groups of rats were anesthetized with enflurane: a control group without impairment of renal function (no. = 7), a group with minimal impairment of renal function (no. = 6) and a group with moderately severe renal impairment (no. = 9). Another group of rats with moderately severe renal impairment (no. = 8) was anesthetized with halothane. Two hours of anesthesia caused mild transient depression of urea clearance in all groups. Six hours of anesthesia caused a 5-10 ml/day increase of urinary output in all groups and small increases in urea N levels in both groups with moderately severe renal impairment. Deterioration of the model was noted late in the experiment, at sacrifice animals were anesthetized with enflurane and 4 with halothane had terminal renal failure. The morphological lesion in both groups was similar, resembling glomerulonephritis. There was no difference in the renal response to enflurane or halothane anesthesia among rats with chronic renal insufficiency.