Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

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Abstract
The formation of the complex of DNA and chloroquine requires the 2-amino group of guanine in DNA; the formation of a similar complex with quinac rine does not depend upon the presence of base-specific binding sites. Quinine interacts with DNA by hydrogen bonding. The 3 drugs and spermine inhibit the DNA-primed DNA polymerase reaction. The RNA polymerase reaction is affected to a lesser extent by the anti-malarial compounds and is either stimulated or inhibited by spermine depending on the concentration of this polyamine.