Parathyroid effects on renal phosphorus excretion in the cow

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Abstract
A pronounced phosphaturic effect of bovine parathyroid extract has been demonstrated previously in monogastric species but not in the cow. To reevaluate this paradox, urinary P, glomerular filtered P, and tubular reabsorbed P were measured in cows while the parathyroid status was varied. Up to 20-fold increase of urinary P in 4 intact cows and up to 900-fold increases in 2 parathyroidectomized cows were observed during a period of daily parathyroid extract administration. After parathyroidectomy, daily urinary P fell to less than 1/70 of control levels. Although in certain instances increased filtered P contributed to an increase of urinary P, appropriate changes in tubular reabsorption of P following parathyroid extract administration and parathyroidectomy indicated that the major increase in the urine P resulted from a depressing effect of parathyroid hormoneupon P reabsorption in the renal tubule.

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