Inhibition of renin secretion by HCl is related to chloride in both dog and rat

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Abstract
To determine if inhibition of renin release by HCl is related to acidosis or to Cl-, the effects of peripheral venous infusions of HCl and H2SO4 on plasma renin activity (PRA) were compared in the dog and the rat. In NaCl-deprived, pentobarbital-anesthetized dogs, either 0.15 M HCl (10) or 0.075 M H2SO4 (7) was infused for 60 min. In 5 of the 10 HCl-infused dogs (group A), urine Cl- excretion increased during HCl infusion. In the remaining 5 dogs (group B), Cl- excretion did not increase. Cl- excretion also did not increase during H2SO4 infusion. Comparable acidosis was produced in all 3 groups. PRA decreased in response to HCl in group A but did not change in group B HCl-infused dogs or in H2SO4 infused dogs. In NaCl-deprived, anesthetized rats, PRA was suppressed by HCl (from 40.6 .+-. 9.4 to 27.4 .+-. 5.3 ng .cntdot. ml-1 .cntdot. h-1 (SE)) but not H2SO4 (from 37.1 .+-. 4.2 to 37.0 .+-. 6.3 ng .cntdot. ml-1 .cntdot. h-1), despite comparable acidosis. Cl- excretion increased only in HCl-infused rats. Inhibition of PRA by acute infusion of HCl is specifically related to Cl-.

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