Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins
- 9 November 2001
- journal article
- other
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 89 (10) , 866-873
- https://doi.org/10.1161/hh2201.100319
Abstract
3-Hydroxy-3-methylglutaryl (HMG)–coenzyme A reductase inhibitors or statins exert direct beneficial effects on the endothelium in part through an increase in nitric oxide (NO) production. Here, we ...Keywords
This publication has 16 references indexed in Scilit:
- Hsp90 Ensures the Transition from the Early Ca2+-dependent to the Late Phosphorylation-dependent Activation of the Endothelial Nitric-oxide Synthase in Vascular Endothelial Growth Factor-exposed Endothelial CellsJournal of Biological Chemistry, 2001
- Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins?Trends in Molecular Medicine, 2001
- Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide SynthaseJournal of Biological Chemistry, 2001
- Hydroxy-Methylglutaryl–Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin AbundanceCirculation, 2001
- The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.Nature Medicine, 2000
- Direct Vascular Effects of HMG-CoA Reductase InhibitorsTrends in Cardiovascular Medicine, 2000
- Current Perspectives on StatinsCirculation, 2000
- New insights into the pharmacodynamic and pharmacokinetic properties of statinsPublished by Elsevier ,1999
- Modulation of the Endothelial Nitric-oxide Synthase-Caveolin Interaction in Cardiac MyocytesJournal of Biological Chemistry, 1998
- Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.Journal of Clinical Investigation, 1997