Subchronic Administration of Caffeine and Theophylline in Drinking Water: Effects on Rat Liver Rna Polymerase Activity
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 4 (2) , 89-100
- https://doi.org/10.3109/01480548108998252
Abstract
Administration of caffeine or theophylline, 0.2 mg/ml (an average of 20 mg/kg/d) of drinking water, to male CD rats, 2 months of age, over a 15 week period resulted in the elevation of liver RNA polymerase I activity by 2–3 fold as assayed in isolated nuclei. This increase in activity was already apparent by the fourth week of exposure. The changes in RNA polymerase I activity were accompanied by moderate liver hypertrophy.This publication has 10 references indexed in Scilit:
- Modification of rat liver RNA polymerase I after in vivo stimulation by hydrocortisone or methylisobutylxanthineJournal of Biological Chemistry, 1978
- Alterations in DNA-dependent RNA polymerases I and II from rat liver by thioacetamide: preferential increase in the level of chromatin-associated nucleolar RNA polymerase IBBiochemistry, 1977
- Enzymology of Cancer CellsNew England Journal of Medicine, 1977
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Mammalian RNA PolymerasesProgress in Nucleic Acid Research and Molecular Biology, 1973
- PHOSPHORUS COMPOUNDS IN ANIMAL TISSUESJournal of Biological Chemistry, 1945
- PHOSPHORUS COMPOUNDS IN ANIMAL TISSUES .1. EXTRACTION AND ESTIMATION OF DESOXYPENTOSE NUCLEIC ACID AND OF PENTOSE NUCLEIC ACID1945