Modulation of hepatic glutathione system of enzymes in suckling mouse pups exposed translactationally to malathion

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Abstract
The present study examines the transmammary modulation of the glutathione system of enzymes in the F1 generation of mouse pups postnatally exposed to malathion. Lactating Swiss albino mice received either 30 or 100 mg malathion kg−1 body wt. (98% pure) for 14 or 21 days postpartum. The acid‐soluble sulphydryl content was significantly increased (PPP−1 body wt. Dams showed an enhanced hepatic glutathione S‐transferase activity following treatment with 100 mg melathion kg−1 body wt. for 14 days (PPS‐transferase activity (PP−1 body wt. daily for 21 days or 100 mg malathion kg−1 body wt. for either 14 or 21 days showed significantly reduced hepatic glutathione peroxidase activity (PPPP<0.02) pups of dams that were treated with the higher dose of malathion.

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