The Indirect Effect of Irradiation on Embryonic Development
- 1 July 1960
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 100 (1) , 94-102
- https://doi.org/10.1001/archpedi.1960.04020040096014
Abstract
Introduction Many factors contribute to the production of congenital malformations. It is the job of the experimentalist to decide what is their relative importance and to uncover all the contributing factors and their interrelationships. This same philosophy applies to congenital malformations caused by one etiology, namely, irradiation. The factors responsible for radiation teratogenesis are multiple and interrelated. Any classification would be completely arbitrary. For the purposes of this paper, the role of radiation can be thought of as mediated directly through the embryo, and indirectly through irradiation of the placenta and/or mother. It is the purpose of this and the subsequent paper to decide on how important these so-called indirect effects are in radiation teratogenesis, and not to determine the nature of these effects. Previous to the work of Wilson, Karr, Jordan, and Brent, all pregnant mammals were given whole-body irradiation, and therefore the direct and indirect factors could notKeywords
This publication has 3 references indexed in Scilit:
- Influence of Severe Hemorrhagic Anemia During Pregnancy on Development of the Offspring in the Rat.Experimental Biology and Medicine, 1953
- Differentiation as a Determinant of the Reaction of Rat Embryos to X-Irradiation.Experimental Biology and Medicine, 1953
- Effects of maternal undernutrition upon thenewborn infant in Holland (1944–1945)The Journal of Pediatrics, 1947