Increased anti-HIV-1 activity of CD4 CDR3-related synthetic peptides by scrambling and further structural modifications, includingd-isomerization and dimerization
- 13 September 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 330 (2) , 117-121
- https://doi.org/10.1016/0014-5793(93)80255-s
Abstract
We recently showed that S1, a sequence-scrambled form of CD4 CDR3-related synthetic peptide, has more potent inhibitory activities on HIV-1 replication and HIV-1-induced syncytium formation than the original form. In this study, a series of derivatives of S1 were synthesized and their anti-HIV-1 activities were evaluated. A d-isomer was as potent as S1, and a homodimer was 10- to 18-fold more potent than S1. The increased antiviral activity of the dimer peptide was related to α-helix formation, as detected by circular dichroismKeywords
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