Synthesis of (−)-Muricatacin via α- and α‘-C−H Bond Functionalization of Tetrahydrofuran
- 28 August 2003
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (19) , 7548-7550
- https://doi.org/10.1021/jo0301696
Abstract
(−)-Muricatacin, a potent cytotoxic (4R,5R)-5-hydroxyheptadecan-4-olide, has been synthesized through α-C−H hydroxyalkylation and α‘-C−H oxidation of tetrahydrofuran. This study presents a novel method for C−H bond functionalization as a means for preparing γ-(hydroxyalkyl)-γ-butyrolactones.Keywords
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