Abstract
Although an elevated serum cholesterol level is well established as one of the most important risk factors for coronary heart disease (CHD), the long-term impact of elevated cholesterol levels in young adults (1 present data from 3 cohorts of younger men from 3 well-known prospective studies that demonstrate a continuous, graded relationship of serum cholesterol levels with long-term risk of CHD, cardiovascular disease (CVD), and all-cause mortality. The authors also demonstrate that compared with younger men with favorable cholesterol levels, those with elevated cholesterol levels have substantial absolute risk and excess risk of death from CHD and CVD as well as shorter estimated life expectancy.