Creatinine Clearance in Normal and Potassium Deficient Rats

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Abstract
Procedures were descr. for the performance in rats of a 30-min. "exogenous" creatinine clearance and a 24-hr. "endogenous" creatinine clearance. Applied to normal rats maintained on a casein diet the two procedures yielded similar avg. values, respectively, 0.72 and 0.62 ml./min./lOO g. body wt. The creatinine clearance of K-deficient rats tended to be reduced. It was also found reduced in rats maintained on a low-protein diet. Since rats on a low-K diet failed to gain wt. as did the control rats, the contribution of K deficiency per se to the lowered creatinine clearance could not be clearly answered. There was found an increased kidney wt. of rats maintained on the low-K diet. Under such a circumstance it was found better to refer the creatinine clearance to body wt. or to body surface than to kidney wt.

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