Effect of the Prolonged Immunization with Tumor-Unrelated Antigen on the Tumor Growth

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Abstract
The effect of prolonged immunization of mice with bovine serum albumin (BSA) or ovalbumin (OA) on the growth of the transplanted, methylcholanthrene-induced fibrosarcoma was studied. When immmune complexes appeared in the kidneys and in the circulation, mice were injected s.c. with various numbers of syngeneic tumor cells. Tumor developed within 17 days in all mice immunized with BSA and injected with 104, 103 and 102 tumor cells and control mice injected with 104 and 103; only 3 of 10 control mice injected with 102 tumor cells developed tumors at that time. All mice immunized with OA and injected with 105, 104 and 103 tumor cells and control mice injected with 105 and 104 developed tumor within 12 days after injection of the tumor cells; in the control group injected with 103 tumor cells, only 6 of 12 mice did so. Weight of the tumors from the mice immunized with BSA or with OA was significantly greater than that of tumors from control mice.