Determination of Lipophilic Character of a Series of Dermorphin-Related Oligopeptioes by Means of Reversed-Phase HPLC

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Abstract
In recent times there has been a growing interest in the determination of chromatographic parameters of lipophilicity with regard to their use in the study of quantitative structure-activity relationship. Very good correlations had been shown between the chromatogaphic parameters and the log P or .pi. values as a measure of the partition coefficient between octanol and water. The reversed phase TLC Rm values in 2 different chromatographic systems and the reversed-phase high performance liquid chromatography log k'' values of a series of dermorphin-related oligopeptides were previously determined. The relationship was studied between log k'' values and Rm or .SIGMA..pi. values in view of QSAR studies. In fact the discovery of enkephalin and endorphins with high affinities for opioid receptors added new dimensions to the study of structure-activity relationship of opioid agonists.