SELECTIVE PROTECTION BY ANGUIDINE OF NORMAL VERSUS TRANSFORMED-CELLS AGAINST 1-BETA-D-ARABINOFURANOSYLCYTOSINE AND ADRIAMYCIN

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (3) , 1135-1137
Abstract
The perferential induction of cytostasis by anguidine in normal WI-38 [human] fibroblasts is reported. This induction occurred at 1/10 of the dosage required to inhibit the cycle progression of WI-38 VA13 cells, the SV40 transformant. Pretreatment with anguidine at a concentration producing effective inhibition of normal cell cycle traverse while permitting sustained proliferation of transformed cells resulted in almost complete protection of WI-38 normal cells against the growth-inhibitory effects of 1-.beta.-D-arabinofuranosylcytosine and Adriamycin, without reducing the antiproliferative effects of these 2 agents against WI-38 VA13 transformed cells. Thus, this cytokinetic concept of preferential normal tissue protection should explored in vivo to increase the therapeutic index of cancer chemotherapy.