Oncogene HER-2 in Canine Mammary Gland Carcinomas
- 1 August 2003
- journal article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 80 (3) , 363-367
- https://doi.org/10.1023/a:1024929730165
Abstract
Immunohistochemical (IHC) HER-2/neu protein overexpression was found in 17.6% of canine mammary gland carcinomas, a percentage similar to that observed in human breast carcinoma, but there was no gene amplification by chromogenic in situ hybridization (CISH). Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification.Keywords
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