VASOCONSTRICTION AND THE DEVELOPMENT OF IRREVERSIBLE HEMORRHAGIC SHOCK

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Abstract
In untreated dogs, the blood flow through such organs as the kidney, liver and intestines during the impending hemorrhagic state may be progressively impaired by (a) arterial hypotension, (b) superimposed vasoconstriction of sympath-ogenic origin and possibly by (c) additional vasoconstriction through liberation and action of humoral agents, the origin and classification of which is not clearly established. To determine the extent to which prolonged vasoconstriction and the consequent protracted impairment of visceral blood flow may influence the rate of transition from impending to irreversible shock, the adrenergic blocking agent, dibenamine, was employed to eliminate factor b and perhaps c above. Its influence upon the survival rate in standardized hemorrhagic shock producing expts. was then analyzed. Initially, the dibenamine was admd. to dogs only 30 min. before hemorrhagic procedures were begun. The progressive influence of the drug for several hrs. after its admn. rendered the cardiovascular conditions at the onset of bleeding extremely unstable. Hence, the original purpose of these expts. was not accomplished. It was felt that the use of the drug in this manner merely rendered the animal''s compensatory adjustments much less efficient.

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