Functional Changes During High Output Failure Produced by Daily Hemorrhage in Dogs with Pulnionic Stenosis

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Abstract
The relationship of changes in cardiovascular and renal hemodynamic function to sodium excretion has been studied following daily hemorrhage in dogs with pulmonic stenosis and in normal dogs. The animals with pulmonic stenosis developed signs of right heart failure, but the normal dogs failed to show evidence of cardiac decompensation during the course of the anemia. The two most striking differences in the responses of the 2 groups of dogs were the increase in mean right atrial pressure and the occurrence of sodium retention, both of which were observed only in the dogs with pulmonic stenosis. The increase in cardiac output and the renal functional changes were similar in the 2 groups of animals; glomerular filtration rate was unchanged or increased in the majority of dogs with pulmonic stenosis and heart failure.