Reevaluation of C-Reactive Protein in Cancer Sera by Radioimmunoassay and Radial Immunodiffusion

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Abstract
C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive method such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM staging and the disease activity at the time of determination. CRP shows a high degree of ‘uniqueness’ when correlated with other routinely used cancer markers such as carcinoembryonic antigen, placental-like alkaline phosphatase and γ-glutamyltranspeptidase.