Acute systemic reactions to carbonless copy paper associated with histamine release
- 8 July 1988
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 260 (2) , 242-243
- https://doi.org/10.1001/jama.260.2.242
Abstract
We report two cases of recurrent episodes of hoarseness, cough, flushing, pruritus, and rash occurring within 30 minutes of topical exposure to carbonless copy paper. Provocative challenges revealed that alkylphenol novolac resin was the ingredient responsible. Video endoscopy of the larynx was performed and plasma histamine levels were obtained prior to and 30 minutes after cutaneous challenge of a patient with alkylphenol novolac resin. We documented marked laryngeal edema and a sixfold increase in plasma histamine levels after challenge. We conclude that topical exposure to carbonless copy paper may cause mast cell/basophil-mediated acute systemic and potentially life-threatening reactions in susceptible patients. (JAMA1988;260:242-243)This publication has 3 references indexed in Scilit:
- Upper Respiratory Irritation From Controlled Exposure to Vapor From Carbonless Copy FormsJournal of Occupational and Environmental Medicine, 1986
- Measurement of plasma histamine: description of an improved method and normal valuesJournal of Allergy and Clinical Immunology, 1982
- Skin and mucous membrane problems from “no carbon required” paperContact Dermatitis, 1981