When the Host Is Smarter Than the Parasite
- 19 April 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 296 (5567) , 482-483
- https://doi.org/10.1126/science.1071206
Abstract
The wily malaria parasite has become resistant to many affordable frontline antimalarial drugs, and new drug targets are desperately needed. Reporting in a Perspective on new work ( Zhang et al.), Goldberg suggests that we look for drug targets among proteins that are shared by the host and parasite but whose synthesis is regulated in a different way.Keywords
This publication has 13 references indexed in Scilit:
- Divergent Regulation of Dihydrofolate Reductase Between Malaria Parasite and Human HostScience, 2002
- Co‐ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysisMolecular Microbiology, 2001
- The intolerable burden of malaria: a new look at the numbersThe American Journal of Tropical Medicine and Hygiene, 2001
- Shotgun DNA microarrays and stage‐specific gene expression in Plasmodium falciparum malariaMolecular Microbiology, 2000
- Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial DrugsScience, 1999
- Chromosome 2 Sequence of the Human Malaria ParasitePlasmodium falciparumScience, 1998
- Dihydrofolate Reductase Protein Inhibits Its Own Translation by Binding to Dihydrofolate Reductase mRNA Sequences within the Coding RegionBiochemistry, 1997
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsPublished by Elsevier ,1994
- Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitroBiochemistry, 1993
- Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.Proceedings of the National Academy of Sciences, 1991