Weitere Beobachtungen zum Stoffwechsel der verfetteten Leber

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Abstract
White mice were used to induce fatty livers with a diet deficient in protein and rich in fats. The concentration of glycogen, pyruvic acid, lactic acid and alpha-ketoglutaric acid were determined for normal and fatty livers ( at 10, 20 and 40 seconds after the death of the animals): the concentrations were somewhat lower in the fatty livers, but there were no gross differences. The rates of utilization of glucose and pyruvic acid by slices from normal and fatty livers were not significantly different from which it is concluded that the high level of fatty deposition (22%) does probably not affect carbohydrate turnover specifically, but only in relation to the N reduction in the metabolically active cell constituents. It was also found that the concentrations of glycogen, pyruvate, lactate and alpha-ketoglutarate are lower in normal liver homogenates than in the intact liver or in liver slices. Addition of pyruvate greatly increased the formation of alpha-ketoglutarate in slices and homogenates.

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