Interaction of Dimethysulfoxide and Ascorbic Acid on Fibroblasts of Rats
- 1 November 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 126 (2) , 354-356
- https://doi.org/10.3181/00379727-126-32443
Abstract
A study was undertaken to determine the ultrastructural effects of dimethylsulfoxide (DMSO) on rat wound fibroblasts and the modifications that ascorbic acid might exert on such changes. Five-day abdominal wounds were bathed in 90% DMSO 1 hr. before biopsy. One group of animals so treated received a total of 300 mg ascorbic acid intraperitoneally during the 48 hr. period preceding biopsy. DMSO alone produced cytoplasmic swelling, loss of cisternal membrane ribosomes, and dilation of the endoplasmic reticulum and mitochondria. Ascorbic acid partially prevented this damage. Ascorbic acid may inhibit the physico-chemical derangement that DMSO induces in the intracellular electron transfer mechanism.This publication has 9 references indexed in Scilit:
- FURTHER OBSERVATIONS ON THE EFFECT OF DIMETHYL SULFOXIDE IN PATIENTS WITH GENERALIZED SCLERODERMA (PROGRESSIVE SYSTEMIC SCLEROSIS)*Annals of the New York Academy of Sciences, 1967
- THE USE OF DIMETHYL SULFOXIDE IN THE TREATMENT OF GENITOURINARY DISORDERSAnnals of the New York Academy of Sciences, 1967
- Inflammation induced by dimethylsulfoxide (DMSO)Experimental and Molecular Pathology, 1967
- THE EFFECT OF DIMETHYL SULPHOXIDE ON HEPATIC CELLS OF RATSImmunology & Cell Biology, 1966
- Hypokalemic periodic paralysisNeurology, 1966
- Dimethyl Sulfoxide in Musculoskeletal DisordersJAMA, 1965
- WOUND HEALING AND COLLAGEN FORMATIONThe Journal of cell biology, 1964
- An electron optical study of experimental scurvyJournal of Ultrastructure Research, 1962
- Studies in familial periodic paralysisExperimental Neurology, 1960