In vitroevaluation of terbinafine and itraconazole against dematiaceous fungi

Abstract
Two hundred and three isolates representing 15 species of filamentous ascomycetes were evaluated against terbinafine and itraconazole using a modification of the NCCLS M27-A standard reference method for yeasts. The MIC ranges and geometric means were similar, although terbinafine tended to have the lowest values. The loculo-ascomycete clade tested had consistently low MIC geometric mean values for its members, ranging from 0·03 to 0·17 µg ml-1 for terbinafine and 0·03–0·37 µg ml-1 for itraconazole.

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