GASTRIC-MUCOSAL HISTAMINE, HISTAMINE FORMATION CAPACITY (HFC) AND PLASMA GASTRIN AFTER CYSTEAMINE ADMINISTRATION

  • 1 January 1984
    • journal article
    • research article
    • Vol. 65  (6) , 759-765
Abstract
Cysteamine administration is followed by stomach and duodenal ulcers in rats. A time relationship was established between changes in gastric mucosal histamine, histamine formation capacity (HFC) and plasma gastrin after cysteamine administration. Up to 4 h after cysteamine s.c. no ulcers were found. Plasma gastrin rose after cysteamine and was higher than in controls 2 h after injection. Mucosal histamine fell after 4 h; no other significant changes were found in mucosal histamine and HFC. A direct correlation was found between plasma gastrin and HFC in both controls and after cysteamine. Evidently, cysteamine releases gastrin, which increases HFC and thus histamine. The fall in histamine seems to indicate utilization of histamine in acid production.