FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE
Open Access
- 1 November 1967
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 126 (5) , 833-849
- https://doi.org/10.1084/jem.126.5.833
Abstract
Data pertaining to the endogenous mouse spleen colony system, 10 days postirradiation, are presented. The Do for visible colonies is 78 R, while that for 6 hr iron uptake over a range of 600–800 R is 50 R. The Do for spleen weight is 196 R and that for IUdR uptake is 193 R. These measurements increase with the age of the mouse. Hypertransfusion decreases spleen iron uptake and colony number. DF-32P and sodium sulfate-35S are not useful indicators of splenic hematopoiesis in this system. Visible hematopoietic colonies in the spleen are not produced by vinblastine, nitrogen mustard, methotrexate, or cyclophosphamide.Keywords
This publication has 35 references indexed in Scilit:
- On Stem-Cell Recovery after IrradiationBritish Journal of Haematology, 1966
- A CONTRIBUTION TO STUDY OF RADIOPROTECTIVE EFFECT OF CYSTAMINE ON HAEMATOPOIETIC STEM CELLS1966
- Pluripotent Stem Cell Function of the Mouse Marrow "Lymphocyte"Science, 1964
- A Simple Method of Obtaining Venous Blood from Small Laboratory AnimalsExperimental Biology and Medicine, 1964
- AN APPROACH TO THE CHARACTERIZATION OF STEM CELLS IN MOUSE BONE MARROWAnnals of the New York Academy of Sciences, 1964
- DEOXYRIBONUCLEIC ACID METABOLISM IN VIVO .I. CELL PROLIFERATION + DEATH AS MEASURED BY INCORPORATION + ELIMINATION OF IODODEOXYURIDINE1964
- A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow CellsRadiation Research, 1961
- Variation of Sensitivity to Ionizing Radiation with AgeNature, 1959
- ACTION OF X-RAYS ON MAMMALIAN CELLSThe Journal of Experimental Medicine, 1956
- Changes in Cell and Plasma Volumes Produced by Total Body X RadiationExperimental Biology and Medicine, 1950