Simultaneous transition of multiple polyps into carcinoma in the large intestine

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Abstract
The histologic grades of multiple neoplastic lesions in the large intestines of 41 patients were studied. Of the 41 patients, 16 had multiple polyps, 12 each had a carcinoma as well as one or more polyps, and the remaining 13 each had two or more carcinomas. Differences in the grades of histologic atypia among multiple neoplastic lesions were minimal. Therefore, the multiple neoplastic lesions present were considered to have airsen simultaneously or successively within a relatively short period of a given patient's life, rather than randomly in different periods. Of 25 patients who had carcinoma in situ or infiltrating carcinoma, 17 had accompanying precancerous conditions or carcinoma elsewhere in the large intestine, and the remaining eight had accompanying nonmalignant polyps.