Bactericidal Action of Streptomycin-Penicillin Mixtures In vitro

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Abstract
Studies were carried out in order to detn. whether streptomycin and penicillin in combination were synergistic in their bactericidal action against 4 common organisms. The minimum lethal concn. of penicillin and of streptomycin was detd. for each organism. In each instance, growth occurred in concns. of 75% or more of this min. lethal concn. Definite synergism was noted in the bactericidal action of penicillin and streptomycin upon staphylococci and streptococci in vitro.